Platelet Recruitment Promotes Keratocyte Repopulation following Corneal Epithelial Abrasion in the Mouse
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منابع مشابه
Platelet Recruitment Promotes Keratocyte Repopulation following Corneal Epithelial Abrasion in the Mouse
Corneal abrasion not only damages the epithelium but also induces stromal keratocyte death at the site of injury. While a coordinated cascade of inflammatory cell recruitment facilitates epithelial restoration, it is unclear if this cascade is necessary for keratocyte recovery. Since platelet and neutrophil (PMN) recruitment after corneal abrasion is beneficial to epithelial wound healing, we w...
متن کاملDelay of corneal epithelial wound healing and induction of keratocyte apoptosis by platelet-activating factor.
PURPOSE To examine the role of the lipid mediator platelet-activating factor (PAF) in epithelial wound healing. METHODS A 7-mm central de-epithelializing wound was produced in rabbit corneas, and the tissue was incubated with 125 nM carbamyl PAF (cPAF), an analogue of PAF. Rabbit corneal epithelial and stromal cells were also cultured in the presence of cPAF. Cell adhesion, proliferation, and...
متن کامل2412 Corneal abrasion stimulates epithelial healing in the other eye
eyf served as a control. Intraperitoneal [Ii ]-thyeidine was injected. Three eyes were studied histologically and autoradiographically at 1 hr, 3 hr. 6 hr. 9 hr, 12 hr, 24 hr, 2 d, 3 d, 9 d, 12 d, 15 d, 18 d and 21 d. The epithelial cells were scanned from limbus to limbus. Analysis of variance and linear regression (SPSS package) were used for statistical evaluation. Results: The cells prolife...
متن کاملCorneal abrasion
CLINICAL QUESTION What is the best treatment for traumatic corneal abrasion? RESULTS Eye patching does not reduce pain in patients with corneal abrasions. Topical diclofenac does reduce pain in patients with corneal abrasions IMPLEMENTATION Pitfalls to avoid when treating abrasions: Treatment of small abrasions Treatment of larger abrasions When to refer for specialist treatment.
متن کاملKeratocyte apoptosis after corneal surgery.
PURPOSE Programmed cell death (apoptosis) is the controlled death of cells that occurs with minimal collateral damage to surrounding cells or tissue during development, homeostasis, and wound healing. The authors hypothesize the keratocyte apoptosis is an initiating factor in the wound-healing response after refractive surgical procedures. To evaluate the effects of different corneal manipulati...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2015
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0118950